Turkish Neurosurgery 2016 , Vol 26 , Num 2
Combination of Curcumin with an Anti-Transferrin Receptor Antibody Suppressed the Growth of Malignant Gliomas In vitro
Xue WEN, Xiaoping CHENG, Dahai HU, Wenmin LI, Jianli HA, Zhaochang KANG, Mingjun ZHANG, Yinghao HUANG, Si WU
Hubei Polytechnic Institute, School of Nursing, Department of Basic Medical, Xiaogan, China DOI : 10.5137/1019-5149.JTN.7966-13.1 AIM: Transferrin receptor (TfR) has been used as a target for the molecular cancer therapy due to its higher expression in a variety of tumors. Anti-TfR antibodies combined with chemotherapeutic drugs has showed great potential as a possible cancer therapeutic strategy. In our study, we investigated the anti-tumor effects of anti-TfR monoclonal antibody (mAb) alone or in combination with curcumin in vitro.

MATERIAL and METHODS: We detected the apoptosis, proliferation and cell cycle of glioma cells after treated with anti-TfR mAb and curcumin alone or the combinations by flow cytometer.

RESULTS: Anti-TfR mAb or curcumin could inhibit proliferation of tumor cells. Anti-TfR mAb marked S phase arrest and curcumin induced G2/M arrest in tumor cells. When anti-TfR mAb and curcumin were used simultaneously, a synergistic effect was detected in relation to tumor growth inhibition and the induction of cells necrosis.

CONCLUSION: These results provided a potential role of anti-TfR mAb-containing curcumin in the treatment for gliomas. Keywords : Chemotherapeutic, Curcumin, Glioma, Transferrin receptor

Corresponding author : Xue Wen, wenxue791203@163.com