Turkish Neurosurgery 2020 , Vol 30 , Num 1
Long-Term Outcomes of Pediatric Meningioma Surgery: Single Center Experience with 23 Patients
1Hacettepe University School of Medicine, Department of Neurosurgery, Ankara, Turkey
2Van Yuzuncuyil Training and Research Hospital, Neurosurgery Clinic, Van, Turkey
3Dicle University School of Medicine, Department of Neurosurgery, Diyarbakir, Turkey
DOI : 10.5137/1019-5149.JTN.27995-19.2 AIM:To evaluate the long-term outcomes and prognostic variables in a surgical cohort of pediatric meningiomas treated in a single institution.

MATERIAL and METHODS: Medical records and follow-up notes of 23 pediatric patients aged <18 years (12 male and 11 female; mean age on presentation, 13.1 ± 4.4 years) harboring 27 meningiomas operated between 1994 and 01/2019 at Hacettepe University Ihsan Dogramaci Children’s Hospital were evaluated.

RESULTS: One patient had neurofibromatosis (NF) type 1, and five patients had NF2. Tumors were most commonly located in the convexity (n=6) and parasagittal or falcine (n=6). Gross total resection was performed in 70.4% of cases. WHO grade I tumors accounted for 56% of all cases, whereas high-grade meningiomas accounted for 44% (33% grade II, 11% grade III). The mean follow-up duration was 10.3 ± 7.7 years. Three patients (13%) died during follow-up, and 76.2% of the patients had favorable outcome (Glasgow Outcome Scale > 3) during the last follow-up assessment. Ten patients (43.5%) had relapse. In univariate analysis, low histological grade (p=0.030) and gross total resection (p=0.024) were associated with favorable outcome. The 10-year overall survival rate was 86%.

CONCLUSION: Meningiomas in the pediatric age group are surgically treatable tumors with fairly good outcomes. However, relapses are common even for low-grade tumors; therefore, long-term surveillance and aggressive treatment are needed. Keywords : Meningioma, Childhood, Surgery, Outcome, Recurrence

Corresponding author : Ilkay ISIKAY, isikay@hacettepe.edu.tr