Turkish Neurosurgery 2021 , Vol 31 , Num 1
Effects of Quetiapine on Neural Tube Development in the Early Stage of Chicken Embryos
1Bakirkoy Research and Training Hospital for Neurology, Neurosurgery and Psychiatry, Department of Neurosurgery, Istanbul, Turkey
2Arnavutkoy State Hospital, Department of Neurosurgery, Istanbul, Turkey
3Marmara University, Faculty of Medicine, Department of Biochemistry, Istanbul, Turkey
4Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Department of Pathology, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.32887-20.1 AIM: To investigate the effects of quetiapine exposure on neural tube development in early stage chicken embryos.

MATERIAL and METHODS: Eighty-four fertilised specific pathogen-free chicken eggs were divided into four equal groups (groups 1?4). Three experimental groups (groups 2, 3 and 4) and a single control group (group 1) were used. Each egg in group 2 (n=21) was injected with 20 ?L of saline after 30 hours of incubation. Eggs in groups 3 and 4 were injected with 0.02 ml of a solution containing 400 and 800 ?g of quetiapine dose, respectively. Incubation was continued until the end of 72 hours. All embryos were then removed from the eggs and histopathologically examined.

RESULTS: Normal development and the closed neural tubes were shown in 18, 16, 13 and 9 embryos in groups 1 2, 3 and 9, respectively, of the 84 embryos incubated. Open neural tubes were found in one, three and five embryos in groups 2, 3 and 5, respectively. Also, developmental anomalies were found in three, four, five and seven embryos in groups 1, 2, 3 and 4, respectively. Moreover, no significant relationship between NTD and quetiapine exposure had been found.

CONCLUSION: Quetiapine has no significant effect on the occurrence of neural tube defects in the chicken embryo model. Keywords : Quetiapine, Second-generation antipsychotics, Neural tube defect, Spina bifida, Chicken embryo

Corresponding author : Gokhan CANAZ, gokhancanaz@gmail.com