Turkish Neurosurgery 2022 , Vol 32 , Num 2
Management of Pregnancy-and Lactation-Related Osteoporosis: Case Series
Murat Hamit AYTAR1,Emel Ece OZCAN EKSI2,Murat Sakir EKSI3,Elvan CEVIZCI AKKILIC4,Zehra Serpil USTALAR OZGEN5,Serdar OZGEN3
1Vocational School of Health Services, Acibadem Mehmet Ali Aydinlar University, Department of First Aid and Reanimation, Istanbul, Turkey
2Bahcesehir University, School of Medicine, Department of Physical Therapy and Rehabilitation, Istanbul, Turkey
3Acibadem Mehmet Ali Aydinlar University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey
4Acibadem Kozyatagi Hospital, Department of Neurology, Istanbul, Turkey
5Acibadem Mehmet Ali Aydinlar University, School of Medicine, Department of Anesthesiology and Reanimation, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.36058-21.1 AIM: To share the experience regarding management and follow-up of patients with Pregnancy- and lactation-related osteoporosis (PLRO) who were effectively treated.

MATERIAL and METHODS: This case series presented 10 patients diagnosed with PLRO and treated from January 2010 to December 2019. Visual analog scale and laboratory findings were evaluated. Spinal and extremity magnetic resonance imaging was obtained for patients with spinal and extremity pains. Dual energy X-ray absorptiometry was used for the measurement of bone mineral density. Values assessed on dual energy X-ray absorptiometry were L1?L4 T score, L2?L4 T score, and femoral neck T score.

RESULTS: In the first-month follow-ups, all patients had meaningful pain relief and symptom resolution. The mean duration of pain control during the treatment period was 2.4 months. Two patients who continued breast-feeding were also the patients whose pain control was achieved at the latest. One patient required vertebroplasty.

CONCLUSION: Patients with PLRO should be promptly treated and followed up. Discontinuation of breast-feeding will provide rapid advantage and should be the first step of the management. Early diagnosis and treatment of calcium and vitamin D with conservative procedures with spinal braces are very important for the treatment of PLRO patients. Additionally, bisphosphonates or teriparatide can improve the bone mineral density in patients with PLRO. Keywords : Pregnancy, Osteoporosis, Vertebroplasty, Lactation, Fracture

Corresponding author : Murat Hamit AYTAR, hamit.aytar@acibadem.edu.tr