Issue release date: 08.03.2024
2Clinical Laboratory Diagnostic Center, General Hospital of Xinjiang Military Region, Urumqi, Xinjiang 830000, China DOI : 10.5137/1019-5149.JTN.38407-22.2 AIM: To study on the association of lnc-MEG3/miR-181b and UCH-L1 in the progression of cerebral hemorrhage. Further facilitation the development of novel strategies that use their potential as a therapeutic targets.
MATERIAL and METHODS: In this study, we studied the lncRNA MEG3 and miR?181b expression in 30 patients with ICH who were admitted to the General Hospital of Xinjiang Military Command from January 2021 to May 2021 by quantitative polymerase chain reaction. Serum levels of UCH-L1 were detected by enzyme?linked immune sorbent assay, and disease severity was evaluated using the Glasgow Coma Scale. We also recorded ICH-related deaths in hospital.
RESULTS: We found that lnc-MEG3 and UCH-L1 levels increased and miR-181b levels decreased in the serum of patients with ICH. lnc-MEG3, miR-181b, and UCH-L1 levels were also associated with the severity of the condition.
CONCLUSION: Our data indicated that lnc-MEG3, miR-181b, and UCH-L1 are likely involved in the pathophysiology of ICH, and could form the basis of future studies on potential targets for the treatment of traumatic CNS injuries. UCH-L1 could also find application in ICH management. Further studies on the plasma lncRNA-MEG3, miR-181b, and UCH-L1 levels in patients with ICH could yield novel biological targets for the prediction and treatment of ICH.
Keywords : Intracerebral hemorrhage, Long non-coding RNA, Ubiquitin C-terminal hydrolase L1, miR-181b