Turkish Neurosurgery 2005 , Vol 15 , Num 4
The Importance of Proliferative Activity and Angiogenesis in Meningioma and Glioma
Esin ATİK1, Yurdal SERARSLAN2, Sevgi BAKARİŞ3, Nazan SAVAŞ4
1Department of Pathology, Medical School, Mustafa Kemal University, Antakya-Hatay, Turkey
2Department of Neurosurgery, Medical School, Mustafa Kemal University, Antakya-Hatay, Turkey
3Department of Pathology, Medical School, Kahraman Maraş, Sütçü İmam University, Kahraman Maraş, Turkey
4Department of Public Health, Mustafa Kemal University, Medical School, Antakya-Hatay, Turkey
OBJECTIVE: The aim of this study was to investigate the usefulness of a mean vascular density (MVD) and proliferative activity labeling index (LI) in gliomas and meningiomas as biological markers in histological grading.

MATERIALS AND METHODS: Our study included 18 cases of glioma and 36 cases of meningioma. These cases were graded according to the WHO classification. CD-34 and Ki-67 immunohistochemical methods were used on paraffin-embedded tissues. Distribution of CD-34 and Ki-67 LI values were determined for different histologic grades of gliomas and meningiomas. The results were analyzed with statistical methods.

RESULTS: In gliomas, the values of Ki-67 were detected as 3.33±2.50 in grade I, 5.01±2.28 in grade III and 10.33±4.85 in grade IV. The mean values of CD-34 were found as 11.80± 9.71 in grade III glioma and 8.40±5.45 in grade IV glioma.

The values of Ki-67 were detected as 4.40±0.40 in atypical, 4.26±4.05 in psammomatous and 3.69±3.24 in meningothelial meningioma. CD-34 expression was 19.60±0.20 in angiomatous meningioma and 6.14±1.91 in malignant meningioma.

CONCLUSION: Our results show that Ki-67 LI and angiogenesis can be useful in tumor grading of gliomas. However, the score of angiogenesis and Ki-67 LI adds little information to predict tumor grade in meningiomas, in contrast to gliomas. Keywords : Meningioma, Glioma, Proliferative activity, Angiogenesis

Corresponding author : Esin Atik, esinatikus@yahoo.com