Chryseobacterium meningosepticum is a gram-negative bacillus that is known to cause meningitis in premature neonates, and a variety of infections in immunocompromised adults. Reports have also identified this agent as a cause of postoperative meningitis in immunocompetent adults. We present the case of a patient with head injury and cerebrospinal rhinorrhea who developed C. meningosepticum meningitis after external ventricular drain placement. It is important that clinicians consider C. meningosepticum as a cause of meningitis in any case that includes blood-brain barrier disturbance and a history of prolonged antibiotic therapy. Keeping a high index of suspicion is the key to rapid diagnosis and prompt treatment of this potentially fatal infection.