Two young male patients with increasing fequency of seizures unresponsive to anti-epileptic drugs are reported. The focal electroencephalographic findings and the lesions revealed by magnetic resonance and x-ray computed tomographic images were compatible with the clinical features of the seizures. Removal of the lesions was performed without the guidance of electrocorticography. Histological examination revealed focal calcifications but could not specify the exact nature of these although extensive clinical and laboratory investigations were performed. The minimal vascular abnormality detected in the centre of the lesions must have triggered the lesions.