AIM: To evaluate the over expression of Glucose-regulated protein 78 kda (GRP78) in recurrent glioblastoma multiforme (GBM) and explore its chemoresatance.

MATERIAL and METHODS: Western blot analysis and real-time PCR were done to detect the expression of GRP78 in GBM tissues.

RESULTS: It was detected that GRP78 is up-expressed in GBM, especially in recurrent GBM. Radiotherapy (RT) plus temozolomide chemotherapy after primary tumor removal in relapsed patients induces C/EBP homologous protein (CHOP).

CONCLUSION: The results mentioned above illustrate an essential function of GRP78 in the pathogenesis of GBM and suggest this receptor as the latest prognostic marker for further GRP78-targeted molecular cancer therapy and potential diagnosis of GMB.