Cerebral radionecrosis is uncommon but important complication of radiation therapy of extracranial and intracranial tumors.In this report we present a case who operated for squamous cell carcinoma of left eyelid and received radiotherapy a total dose of 5250cGy after operation 18 months before admission. She admitted to our clinic with headache and generalized seizures which started in last month. Cranial MRI showed a dense lesion about 4x4 cm. in the left frontal lobe. The patient was operated and mass was removed totally. Histopathological findings were regarded as vascular changes secondary to radiotherapy and coagulative necrosis. Based on a review of the literature a possible mechanism of necrosis, treatment methods and clinical outcome are discussed.