AIM: Intracranial hypodense lesions include a wide group of pathologies with different structures and characters. Although the radiological imaging properties of these neoplastic and non-neoplastic lesions are similar, treatment modalities for each lesion differs due to histopathological structure.

MATERIAL and METHODS: In this study we have compared the results of radiological and scintigraphic evaluations with the results of stereotaxic biopsies to figure out the diagnostic impact of these non-inasive modalities. 16 patients who admitted to outpatient clinics with headache and/or seizure complaints were included in the study.

RESULTS: MR spectroscopic images diagnosed the lesions as accurately as stereotaxic biopsies.

CONCLUSION: Although stereotaxic biopsy keeps the label of “gold standard” when establishing a diagnosis for these lesions, modern radiological modalities are quite reliable.