E-ISSN: 1019-5157
ISSN: 2651-5024
Vol. 34, Issue 6 (2024)
Full Metin PDF
Turkish Neuro -Excursion
General Neurosurgery and Miscellaneous-Others
Surviving the Big One: Turkish Neurosurgical Society's Innovative Disaster Management Model for Istanbul Earthquake
Pages: 941-945
DOI: 10.5137/1019-5149.JTN.46154-23.2
The Turkish Neurosurgical Society (TNS) played a pivotal role in providing critical medical support during the Kahramanmaraş
earthquake. Recognizing the urgent need for neurosurgeons, our team collaborated with various institutions to address material
shortages and meet medical requirements. Howev...
Original Investigation
Spine and Peripheral Nerves
Use of 3- Dimensional Modeling and Virtual Reality in the Education of Posterior Spinal Instrumentation
Pages: 958-965
DOI: 10.5137/1019-5149.JTN.46204-24.1
AIM: To assess the effectiveness and safety of Virtual Reality (VR) simulations for education of posterior spinal instrumentation.
MATERIAL and METHODS: Participants were instructed to apply Cervical-Thoracic-Lumbar and Sacral posterior instrumentation
techniques using the VR. Each participant und...
Neuroanatomy
Medial Pontine Area: A Safe Entry to the Brainstem as a Cut Above the Rest
Pages: 966-972
DOI: 10.5137/1019-5149.JTN.45710-23.1
AIM: To examine the fiber-based anatomy of the medial pontine area (MPA), one of the most commonly used brainstem (BS) safe
entry zones in neurosurgery.
MATERIAL and METHODS: According to the protocol of Klingler and Ludwig, six BSs were kept in 10% formalin solution for at
least 2 months. After ...
Neuroanatomy
Anatomy of the Petrosphenoidal Ligament and Its Relationship with the Abducens Nerve in Newborn Cadavers
Pages: 973-979
DOI: 10.5137/1019-5149.JTN.44104-23.2
AIM: To examine the anatomy of the petrosphenoidal ligament (PSL), and its relationship with the abducens nerve (AN) in newborn
cadavers.
MATERIAL and METHODS: Using 10 formalin-fixed newborn cadavers, 20 PSLs and ANs on both sides were examined.
The structure of each PSL, its morphometric featur...
Neuroanatomy
Morphometric Development of Medial Surface of Cerebrum in Fetal Cadavers
Pages: 980-990
DOI: 10.5137/1019-5149.JTN.44965-23.4
AIM: To investigate the morphometric and morphological development of the medial surface of the cerebrum in 40 fetal cadavers
without external anomalies and pathologies between the gestational ages of 22 and 40 weeks.
MATERIAL and METHODS: In this study, we measured the height and width of the cer...
Neuro-Oncology
Impact of Tumor Resection Volume on Visual Outcomes and the Need for Secondary Surgery Following Transsphenoidal Surgery in Suprasellar Extended Non-Functionial Pituitary Adenomas
Pages: 991-998
DOI: 10.5137/1019-5149.JTN.45315-23.2
AIM: To investigate the surgical outcomes in patients with nonfunctional pituitary adenomas (NFPAs) exhibiting visual field defects
(VFDs) in order to ascertain the impact of the volume of adenoma excised during surgery on recurrence rates and improvements in
VFDs.
MATERIAL and METHODS: From a co...
Neuro-Oncology
Molecular Subgrouping Based on Immunohistochemistry in Medulloblastoma: A Single-Center Experience
Pages: 999-1008
DOI: 10.5137/1019-5149.JTN.45863-23.2
AIM: To investigate the efficacy of immunohistochemical methods to determine molecular subgroups and prognostic predictions
of medulloblastomas (MBs).
MATERIAL and METHODS: ?-catenin, GAB1, YAP1, filamin A and p53 were immunohistochemically stained, and MYC and MYCN
fluorescent in situ hybridizat...
Neuro-Oncology
Outlining the Molecular Profile of Glioblastoma: Exploring the Influence of Subventricular Zone Proximity
Pages: 1009-1015
DOI: 10.5137/1019-5149.JTN.45105-23.3
AIM: To investigate the correlation between specific glioblastoma multiforme (GBM) molecular markers and their proximity to the
subventricular zone (SVZ) to uncover potential prognostic indicators and therapeutic strategies.
MATERIAL and METHODS: The study retrospectively analyzed 171 patients who...
Neuro-Oncology
Relationship of Serum Microsomal Prostaglandin E2 Levels with Residual Tumor Volume in Patients with Astrocytoma
Pages: 1016-1022
DOI: 10.5137/1019-5149.JTN.45184-23.3
AIM: To investigate the relationship between tumor volume and serum microsomal prostaglandin E2 (mPGE2) levels in patients with
astrocytic tumors.
MATERIAL and METHODS: The study included patients with astrocytic tumors who were treated at our clinic between August
2015 and December 2016. Preoper...
Cerebrovascular-Endovascular
Outcomes of Surgical and Endovascular Treatment of Intracranial Aneurysms: A Single-Center Analysis of 1183 Patients
Pages: 1023-1029
DOI: 10.5137/1019-5149.JTN.44988-23.3
AIM: To compare the treatment outcomes of surgical and endovascular methods in patients with intracranial aneurysms.
MATERIAL and METHODS: A total of 1183 patients [722 (61%)] female and 461 [(39%) male] with intracranial aneurysms, including
615 with subarachnoid hemorrhage (SAH) and 568 without ...
Cerebrovascular-Endovascular
The Role of Different Antioxidant Pathways Like AKT, SIRT-1, NRF2 and HO-1 in Cardiac Damage After Subarachnoid Hemorrhage
Pages: 1030-1039
DOI: 10.5137/1019-5149.JTN.45964-23.3
AIM: To explore the pathophysiological mechanism of subarachnoid haemorrhage (SAH) using cellular oxidative stress mechanisms
and inflammation.
MATERIAL and METHODS: A total of 20 Wistar Albino rats were divided into two groups, namely sham and SAH. On day 0, 0.3
mL of saline in the sham group an...
Cerebrovascular-Endovascular
Evaluations of Oxidative Stress, Thiol/Disulphide Homeostasis, and Nitric Oxide in Patients with Aneurysmal Subarachnoid Hemorrhage
Pages: 1040-1049
DOI: 10.5137/1019-5149.JTN.45638-23.2
AIM: To investigate changes in nitric oxide (NO) levels, oxidative stress, and dynamic thiol/disulphide homeostasis in the serum and
cerebrospinal fluid (CSF) of patients with aneurysmal subarachnoid hemorrhages (aSAH).
MATERIAL and METHODS: This prospective study included a total of 40 consecutiv...
Spine and Peripheral Nerves
Correlations Between Facet Tropism, Joint Mobility and Degree of Displacement in Patients with Low Grade Spondylolisthesis
Pages: 1050-1055
DOI: 10.5137/1019-5149.JTN.40720-22.3
AIM: To compare lumbar X-ray and magnetic resonance imaging (MRI) findings, and to identify the factors associated with joint
instability in cases with lumbar spondylolisthesis.
MATERIAL and METHODS: We performed a retrospective and observational study of patients with a confirmed diagnosis of
lu...
Neuro-Oncology
Predictive Value of T2-weighted Perfusion and T1-weighted Permeability MRI Parameters in Determining IDH Mutational Status and Grade of Gliomas
Pages: 1056-1065
DOI: 10.5137/1019-5149.JTN.46251-24.3
AIM: To assess the performance metrics of perfusion and permeability magnetic resonance imaging (MRI) parameters with optimal
cut-offs in differentiating isocitrate dehydrogenase (IDH) genotype and tumor grade in patients with grade 2-4 gliomas.
MATERIAL and METHODS: This retrospective study inclu...
Spine and Peripheral Nerves
Can Qualitative Cervical Tractography Predict Clinical Findings as Effectively as It Aids Surgical Planning Today?
Pages: 1066-1072
DOI: 10.5137/1019-5149.JTN.46234-24.1
AIM: To investigate cervical spinal tractography (CST) and diffusion tensor imaging findings in patients with intramedullary cervical
spinal cord (CSC) tumors and to evaluate the association between qualitative diffusion tensor tractography (DTT) findings and
neurological examination findings (NEF...
General Neurosurgery and Miscellaneous-Others
Intracranial Arachnoid Cysts in Adulthood: A Retrospective, Multicenter Magnetic Resonance Imaging-Based Study
Pages: 1073-1080
DOI: 10.5137/1019-5149.JTN.44188-23.3
AIM: To retrospectively evaluate the cranial magnetic resonance imaging (MRI) features and determine the incidence of intracranial
arachnoid cysts (ACs) based on sex, age, location, size, affected side, Galassi type, and their association with hydrocephalus, mega
cisterna magna (MCM), bone erosion...
General Neurosurgery and Miscellaneous-Others
Analysis of the Cranial Aperture of the Optic Canal in Patients with Chiari Type-I Malformation
Pages: 1081-1092
DOI: 10.5137/1019-5149.JTN.45482-23.2
AIM: To examine the morphological properties of the cranial aperture of the optic canal (CAOC) in patients with a Chiari type-I
malformation (CIM).
MATERIAL and METHODS: Radiological images of 40 patients with CIM (24 females/16 males, mean age: 20.75 ± 14.98 years) and
40 normal individuals (24 ...
General Neurosurgery and Miscellaneous-Others
The Utility of Neuroendoscopic Approach for Pineal Region Lesions: Single-Centre Experience
Pages: 1093-1101
DOI: 10.5137/1019-5149.JTN.44904-23.4
AIM: To investigate the treatment approaches and follow-up data of patients with pineal region tumours at our institution.
MATERIAL and METHODS: A retrospective study was planned to evaluate patients who diagnosed with a pineal mass between
2019 and 2022 whether incidentally or symptomatically. Al...
Neurotrauma
Nonacute Subdural Hematoma Evacuation Using a Rigid Endoscopy System: A Clinical Study
Pages: 1102-1109
DOI: 10.5137/1019-5149.JTN.46194-23.2
AIM: To determine the clinical relevance of a rigid endoscopy surgical method for subdural hematomas, as previously described in
a cadaver study.
MATERIAL and METHODS: Between May 2021 and September 2023, 21 patients underwent subdural hematoma drainage using a
0-degree rigid endoscope. Traumatic...
General Neurosurgery and Miscellaneous-Others
Experimental Feasibility Study of TRAIL Gene Transfected into Neural Stem Cells
Pages: 1110-1116
DOI: 10.5137/1019-5149.JTN.35812-21.7
AIM: To investigate the feasibility of transfecting the TNF-related apoptosis-inducing ligand (TRAIL) gene into neural stem cells
(NSCs) in vitro, and explore whether NSCs retain their proliferative and differentiated activities after transfection.
MATERIAL and METHODS: NSCs were obtained from fet...
Neurotrauma
Trolox Reduces Neuroblastoma-Induced Oxidative Stress and Inflammation
Pages: 1117-1121
DOI: 10.5137/1019-5149.JTN.46442-24.4
AIM: To determine the effects of different concentrations of Trolox on the cytotoxic, oxidant, antioxidant, and cytokine levels in the
SH-SY5Y cell line.
MATERIAL and METHODS: SH-SY5Y cells were grown in an appropriate medium and under appropriate conditions. Trolox was
added to the cell line at ...
Neurotrauma
Mediation of Epigenetic Mechanisms in the Regenerative Effect of Uridine in a Rat Model of Sciatic Nerve Injury
Pages: 1122-1132
DOI: 10.5137/1019-5149.JTN.45425-23.2
AIM: To investigate the possible mediation of epigenetic mechanisms underlying the regenerative effect of uridine in a sciatic nerve
transection rat model.
MATERIAL and METHODS: Fifty adult male rats were randomized to sham, control, and uridine groups. After unilateral transection
and primary an...
Neurotrauma
Amantadine's Neuroprotective Effects in Rabbit Spinal Cord Ischemia/Reperfusion Model
Pages: 1133
DOI: 10.5137/1019-5149.JTN.45875-23.3
AIM: To examine the effects of amantadine, a drug with neuroprotective and anti-inflammatory activities on oxidative stress, tissue
necrosis, apoptosis, and neurological recovery in an experimental rabbit spinal cord ischemia-reperfusion injury (SCIRI) model.
MATERIAL and METHODS: A total of 32 ra...
Neurotrauma
Effects of Vitamin D and Memantine on Repetitive Mild Traumatic Brain Injury via mTOR, TRPM2, and GABA Expression Levels on Juvenile Rats
Pages: 1146-1159
DOI: 10.5137/1019-5149.JTN.44980-23.3
AIM: To investigate the effects of vitamin D and memantine on the healing process in juvenile rats with repetitive brain injury (rTBI)
and to elucidate the mechanisms underlying these potential therapeutic effects.
MATERIAL and METHODS: Juvenile rats were randomly allocated into seven groups, with...
Case Report
Spine and Peripheral Nerves
Neglected Case of Cervical Meningocele in an Adult
Pages: 1161-1165
DOI: 10.5137/1019-5149.JTN.45997-23.2
Neural tube defects (NTD), caused by a disturbance in the neurulation process, are easily diagnosed and treated in the early years of
life. Although early repair of NTD is advocated, there is lacking information on its natural course. There are only 11 cases, including
this one, reported in litera...