E-ISSN: 1019-5157
ISSN: 2651-5024
Vol. 35, Issue 1 (2025)
Full Metin PDF
Special Article
Pages: 001-002
DOI: 10.5137/1019-5149.JTN.46896-24.3
Original Investigation
Education in Neurosurgery
Alternative Magnification Devices for Microsurgical Training: Comparative Analysis
Pages: 012-021
DOI: 10.5137/1019-5149.JTN.43537-23.2
AIM: To determine if low-cost magnification devices (USB computer microscope, smartphone) enable the acquisition and maintenance
of basic microsurgical skills by comparing skills learned using these devices against those learned using a surgical microscope.
Determining whether skills acquired usin...
Neuro-Oncology
Clinicopathological and Prognostic Significance of Tim-3 and Rel-B Expressions in Grade 4 Diffuse Gliomas
Pages: 022-033
DOI: 10.5137/1019-5149.JTN.43568-23.2
AIM: To assess the clinicopathological and prognostic significance of Tim-3, an immune checkpoint molecule, and Rel-B, an NF-?B
subunit, in grade 4 diffuse glioma samples and their relationship with each other.
MATERIAL and METHODS: The demographic, radiologic, treatment, and prognostic data of pa...
Neuro-Oncology
Prognostic Utility of Albumin-to-gamma-Glutamyltransferase Ratio in Patients with High-Grade Glioma and the Development of a Nomogram for Overall Survival
Pages: 034-045
DOI: 10.5137/1019-5149.JTN.46130-23.2
AIM: To assess the prognostic utility of the albumin-to-gamma-glutamyltransferase ratio (AGR) in patients with high-grade glioma
[World Health Organization (WHO) grade III and IV] and to develop a predictive nomogram.
MATERIAL and METHODS: Data from 185 patients diagnosed with high-grade gliomas, ...
Neuro-Oncology
Cytotoxic Effects of Hypericum Perforatum on Glioblastoma Cells by Inducing Oxidative Stress, Autophagy and Apoptosis
Pages: 046-055
DOI: 10.5137/1019-5149.JTN.45958-23.3
AIM: To identify the autophagy mechanism T98 glioma cells.
MATERIAL and METHODS: Three groups were created with T98 human glioblastoma cells; Group 1: T98 glioma cells without
treatment (Control group). Group 2: T98 glioma cells treated with 3 µl/ml JWO. Group 3: T98 glioma cells treated with 6 µl...
Neuro-Oncology
Is Unilateral Extended Pterional Craniotomy Adequate Instead of Bicoronal (Bifrontal) Craniotomy in Large or Giant Olfactory Groove Meningiomas?
Pages: 056-061
DOI: 10.5137/1019-5149.JTN.46246-24.3
AIM: To evaluate the radiological characteristics, clinical features,and surgical outcomes of bicoronal incision and bifrontal
craniotomy for olfactory groove meningiomas (OGMs).
MATERIAL and METHODS: This was a retrospective review of 16 patients (nine male and seven female) with large and giant
...
Cerebrovascular-Endovascular
Evaluation of Postoperative Prognosis on Carotid Endarterectomy: Single Center Experience
Pages: 062-067
DOI: 10.5137/1019-5149.JTN.46537-24.2
AIM: To determine the prognostic value of routine hematological indices in patients undergoing carotid endarterectomy (CEA).
MATERIAL and METHODS: As a retrospective single center study, we measured the systemic immune inflammation index (SII)
and other systemic inflammatory parameters to estimate...
Cerebrovascular-Endovascular
Impact of Obesity on Subarachnoid Hemorrhage-Induced Cerebral Vasospasm: An Experimental Rat Model
Pages: 068-075
DOI: 10.5137/1019-5149.JTN.47241-24.3
AIM: To investigate the effect of obesity on the severity of cerebral vasospasm after subarachnoid hemorrhage.
MATERIAL and METHODS: In this study, six experimental groups, each consisting of 10 rats, were defined (60 rats in total). Groups
1 and 2 comprised rats with normal body weight, Groups 3 ...
Pediatrics
Morphometry of Latissimus Dorsi in Fetal Cadavers for Prenatal Spina Bifida Surgery
Pages: 076-089
DOI: 10.5137/1019-5149.JTN.44547-23.4
AIM: To investigate latissimus dorsi morphometry, innervation, vascularization, and variational situations in fetuses.
MATERIAL and METHODS: Forty-nine fetuses, aged between 15 and 40 weeks of gestation, were examined for the morphological
development of the latissimus dorsi. The horizontal length...
Pediatrics
Relationship Between Defect Volume and Comorbid Pathologies in Patients Undergoing Surgery for Myelomeningocele
Pages: 090-094
DOI: 10.5137/1019-5149.JTN.46011-23.3
AIM: To determine sac volume based on radiological examinations in patients undergoing surgery for myelomeningocele (MMC) and
to investigate the relationship of sac volume with hydrocephalus and Chiari malformation type 2 (CM) with a view to determining the
optimum length of follow-up and recommen...
Pediatrics
Supratentorial Intracranial Anomalies in Myelomeningocele Patients
Pages: 095-100
DOI: 10.5137/1019-5149.JTN.44183-23.7
AIM: To assess associated cerebral supratentorial anomalies in patients who underwent myelomeningocele repair in hopes of
developing a better morphological apprehension of the forebrain?s anomalies in this category of patients.
MATERIAL and METHODS: This retrospective observational study assessed ...
Spine and Peripheral Nerves
Retrospective Evaluation of Radiological and Clinical Postoperative Findings of Patients Who Had Endoscopic Lumbar Discectomy
Pages: 101-111
DOI: 10.5137/1019-5149.JTN.45972-23.2
AIM: To evaluate the postoperative magnetic resonance imaging (MRI) findings and clinical outcomes of patients who underwent
monoportal endoscopic lumbar discectomy.
MATERIAL and METHODS: Preoperative and postoperative 3rd and 6th month MRI features, visual analog scale (VAS), and
Oswestry Disabi...
Spine and Peripheral Nerves
Posterior Dynamic/Semi-Rigid Stabilization as an Effective Treatment for Cervical Spinal Stenosis
Pages: 112-119
DOI: 10.5137/1019-5149.JTN.45158-23.3
AIM: To investigate the short- term results of dynamic/semi-rigid stabilization in patients with cervical spinal stenosis and compare
them with patients for which decompression and pos-terior cervical fusion was performed.
MATERIAL and METHODS: 28 patients were included in this study. Group 1 was ...
Spine and Peripheral Nerves
The Effect of Obesity on the Treatment Outcomes of Lumbar Transforaminal Epidural Steroid Injections
Pages: 120-128
DOI: 10.5137/1019-5149.JTN.45956-23.3
AIM: To investigate the effects of obesity on the treatment outcomes of lumbar transforaminal epidural steroid injections (TFESIs).
MATERIAL and METHODS: This retrospective study included patients who underwent single-level TFESI in a pain management
center between January 2021 and April 2023. Bod...
Spine and Peripheral Nerves
Evaluation of the Effects of HDAC Activity in Hydroxychloroquine Applied Human Primary Chondrocyte and Nucleus Pulposus Cultures
Pages: 129-140
DOI: 10.5137/1019-5149.JTN.46503-24.2
AIM: To evaluate the in vitro effects of hydroxychloroquine (HCQ) on histone deacetylase (HDAC) enzyme activity and interleukin
(IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-α) expressions.
MATERIAL and METHODS: Primary cell cultures were prepared. Samples that did not receive any medic...
Stereotactic and Functional
Assessing the Potential of Transorbital and Supraorbital Approaches for Stereotactic Surgery: An Anatomical Feasibility Study
Pages: 141-156
DOI: 10.5137/1019-5149.JTN.46170-23.2
AIM: To evaluate the supraorbital and transorbital approaches as alternative entry sites and trajectories targeting the nucleus
accumbens (NAc), subcallosal cingulate gyrus (SCG), and lateral hypothalamic area (LHA), in cadavers and surgical planning station.
MATERIAL and METHODS: The three-dimens...
General Neurosurgery and Miscellaneous-Others
Analysis of Intracranial Compliance Through Noninvasive Intracranial Pressure Waveforms in Hydrocephalus Patients. A Pilot Study
Pages: 157-163
DOI: 10.5137/1019-5149.JTN.45668-23.2
AIM: To assess the changes of intracranial pressure waveforms (ICPW) acquired noninvasively in a set of acute hydrocephalus
patients prior to and posterior to interventions.
MATERIAL and METHODS: Patients with clinical and radiological diagnosis of hydrocephalus were evaluated for alterations in
...
General Neurosurgery and Miscellaneous-Others
Efficacy and Safety of Guideless Catheter Placement Technique in Revision External Ventricular Drainage and Ventricular Shunt Surgery
Pages: 164-170
DOI: 10.5137/1019-5149.JTN.46944-24.2
AIM: To evaluate the efficacy and safety of the guideless catheter placement technique in revision surgeries for external ventricular
drainage (EVD) and ventricular shunt systems to improve treatment outcomes for hydrocephalus.
MATERIAL and METHODS: We retrospectively analyzed 111 patients who und...
General Neurosurgery and Miscellaneous-Others
Evaluation of the Sella Morphology in Chiari Malformation Type I
Pages: 171-181
DOI: 10.5137/1019-5149.JTN.45939-23.3
AIM: To investigate the morphology of sella turcica (ST) in Chiari malformation type I (CM-I) using computed tomography.
MATERIAL and METHODS: The size and shape of ST were examined using the radiological images of 32 CM-I patients (21
female/11 male, mean age: 26.09 ± 15.39 years), and 32 normal ...
Case Report
Pages: 182-188
DOI: 10.5137/1019-5149.JTN.44217-23.5
Erdheim-Chester Disease is a rare systemic xanthogranulomatous infiltrating disease, characterized by lipid-laden histiocytes
accumulating in various organs and almost always in bones. Etiology of the disease is still unknown. It may involve various organs
and systems, such as musculoskeletal, car...