E-ISSN: 1019-5157
ISSN: 2651-5024
Case Report
Primary Solitary Intracranial Lymphomatoid Granulomatosis: A Case Report and Literature Review
Liusong Yang✉ ,
Mingzhe Zheng
Neurosurgery, Huashan Hospital, Fudan University; Neurosurgery, Huashan Hosiptal, Fudan University
DOI: 10.5137/1019-5149.JTN.51719-26.2
Accepted: 18/09/2026
Article in Press
Corresponding Author:
Liusong Yang (yangls72@hotmail.com)
Abstract
AIM: Lymphomatoid granulomatosis (LYG) is a rare EpsteinBarr virusassociated B-cell lymphoproliferative disorder. Primary central nervous system (CNS) involvement, particularly as a solitary intracranial lesion, is extremely uncommon and poses significant diagnostic challenges. We report a rare case of primary solitary intracranial LYG and review the relevant literature.
CASE DESCRIPTION: A 62-year-old woman presented with left-sided limb weakness, headache, and dizziness. Brain magnetic resonance imaging revealed a ring-enhancing lesion in the right frontal lobe with extensive edema, initially suspected to be glioma. The patient underwent gross total resection. Histopathological examination confirmed grade I lymphomatoid granulomatosis with EpsteinBarr viruspositive B cells. Postoperative whole-body positron emission tomography showed no systemic involvement. The patient was treated with interferon-α1b. No recurrence was observed during 1-year follow-up.
CONCLUSION: Primary solitary intracranial LYG is extremely rare and may mimic other intracranial tumors radiologically. Histopathological examination remains essential for diagnosis. Surgical resection followed by immunomodulatory therapy may be an effective treatment strategy for low-grade disease.
CASE DESCRIPTION: A 62-year-old woman presented with left-sided limb weakness, headache, and dizziness. Brain magnetic resonance imaging revealed a ring-enhancing lesion in the right frontal lobe with extensive edema, initially suspected to be glioma. The patient underwent gross total resection. Histopathological examination confirmed grade I lymphomatoid granulomatosis with EpsteinBarr viruspositive B cells. Postoperative whole-body positron emission tomography showed no systemic involvement. The patient was treated with interferon-α1b. No recurrence was observed during 1-year follow-up.
CONCLUSION: Primary solitary intracranial LYG is extremely rare and may mimic other intracranial tumors radiologically. Histopathological examination remains essential for diagnosis. Surgical resection followed by immunomodulatory therapy may be an effective treatment strategy for low-grade disease.
Keywords
Lymphomatoid granulomatosis
Central nervous system
Intracranial tumor
Interferon-alpha
Case report