E-ISSN: 1019-5157
ISSN: 2651-5024
Vol. 36, Issue 3 (2026)
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Systematic Review
Pages: 341-348
DOI: 10.5137/1019-5149.JTN.49284-25.1
AIM: To assess the effectiveness and safety of endovascular treatment (EVT) versus medical management (MM) in stroke patients with premorbid disabilities.
MATERIAL and METHODS: A systematic search was conducted in PubMed, Embase, and the Cochrane Library for studies on EVT in large vessel occlusion...
Pages: 349-359
DOI: 10.5137/1019-5149.JTN.47617-24.5
AIM: Rachiphagus is a rare congenital anomaly in which conjoined twins are fused at the midline of the vertebral column region. When one twin is malformed, the condition is referred to as a parasitic twin. The term "parasitic twin" also encompasses cases involving extra limbs or limb-like structures...
Original Investigation
Cerebrovascular-Endovascular
Brainstem Cavernoma: A Benign Lesion in a Malignant Location
Pages: 360-370
DOI: 10.5137/1019-5149.JTN.48860-25.2
AIM: To present our surgical experience with brainstem cavernomas and to emphasize the importance of the brainstem's internal structures.
MATERIAL and METHODS: Based on the clinical data of 25 symptomatic patients who underwent surgery for brainstem cavernomas, we reviewed their radiological findin...
Neuro-Oncology
Downregulation of miR-221, miR-143, and miR-22 in Meningioma: Diagnostic Performance in a Single-Center Case–Control Study
Pages: 371-376
DOI: 10.5137/1019-5149.JTN.49747-25.3
AIM: To determine case-control differences in tissue miRNA expression and to quantify their ability to distinguish meningioma from nontumor dura. MATERIAL and METHODS: Tissue samples from 45 intracranial meningioma cases (WHO grade I, n = 22; grade II, n = 23) and 26 dura controls were analyzed. miR...
Neuro-Oncology
Ferulic Acid Increases Temozolomide Sensitivity in Glioblastoma Cells, Causing DNA Damage and Inhibiting Cell Proliferation
Pages: 377-384
DOI: 10.5137/1019-5149.JTN.49811-25.3
AIM: To investigate the antitumor effects of ferulic acid (FA) on glioblastoma multiforme (GBM) cells both alone and in combination with temozolomide (TMZ), and also to determine the potential of this synergy for treatment processes. MATERIAL and METHODS: Human glioblastoma U87-MG cells were used in...
Spine and Peripheral Nerves
Investigation of Age-Related Changes of the Atlas for Posterior Cervical Screw Fixation Surgery: A Morphometric Computed Tomography Study
Pages: 385-393
DOI: 10.5137/1019-5149.JTN.49164-25.2
AIM: To describe the morphometry of the atlas vertebrae regarding sex and age in posterior cervical surgery, provide a data source for surgery, and compare with other populations. In surgical operations, the morphology and morphometry of the atlas must be known.
MATERIAL and METHODS: Computed tomog...
Spine and Peripheral Nerves
A Comprehensive Assessment of Clinical, Radiological, and Histopathological Parameters in Lumbar Disc Herniation Using Correlation Matrices Analysis
Pages: 394-405
DOI: 10.5137/1019-5149.JTN.49270-25.2
AIM: To provide deeper insights into the biological mechanisms underlying disc degeneration and recurrence by studying histopathological features of excised disc tissue. Moreover, due to limited predictive role of radiological grading systems like Pfirrmann and Modic classifications in understanding...
Spine and Peripheral Nerves
Anterior Contralateral Cervical Microdiscectomy at C7-T1
Pages: 406-412
DOI: 10.5137/1019-5149.JTN.49227-25.2
AIM: To retrospectively review the patients who had disc herniation at C7-T1 level and were treated using the senior author's anterior contralateral simple microdiscectomy without fusion technique.
MATERIAL and METHODS: From January 2000 to December 2021, 27 patients underwent surgery for C7-T1 dis...
Spine and Peripheral Nerves
A New Measurement Technique for Lumbosacral Transitional Vertebra and Anatomic Orientation of Sacrum (Perioperative Indicator for Lumbosacral Surgery)
Pages: 413-419
DOI: 10.5137/1019-5149.JTN.49317-25.3
AIM: To evaluate the orientation of the sacrum, its influence on sagittal balance, and its practical relevance in identifying a sacralized L5 or lumbarized S1 as a lumbosacral transitional vertebrae (LSTV) to help prevent complications. MATERIAL and METHODS: Lumbosacral vertebral roentgenograms from...
Spine and Peripheral Nerves
Lumbar Function and Muscle Preservation Following Hybrid Surgery Versus Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis: A Preliminary Comparative Study
Pages: 420-432
DOI: 10.5137/1019-5149.JTN.49086-25.3
AIM: To investigate lumbar motion and muscle change following hybrid surgery in adolescent idiopathic scoliosis (AIS).
MATERIAL and METHODS: We conducted a prospective study design including 16 patients (14 female, 2 male) who underwent either hybrid surgery or selective thoracic fusion surgery (ST...
Spine and Peripheral Nerves
Patterns of Pedicle Wall Violations Following Thoracolumbar Stabilization in Osteoporotic and Non-Osteoporotic Patients
Pages: 433-439
DOI: 10.5137/1019-5149.JTN.49543-25.2
AIM: To investigate which pedicle level and wall were most affected by screw malposition in osteoporotic and non-osteoporotic patients undergoing thoracolumbar stabilization, and to determine whether significant differences existed between the groups. MATERIAL and METHODS: This retrospective study a...
Stereotactic and Functional
Long-Term Outcomes of Anterior Temporal Lobectomy in Adults with Temporal Lobe Epilepsy: A Comprehensive Analysis of a 20-Year, 168-Patient Cohort
Pages: 440-449
DOI: 10.5137/1019-5149.JTN.48548-25.4
AIM: To evaluate the long-term clinical outcomes and histopathological classifications of anterior temporal lobectomy in adult patients with mesial temporal lobe epilepsy (TLE) associated with hippocampal sclerosis.
MATERIAL and METHODS: This was a retrospective study of 168 adult patients diagnose...
Pediatrics
Brain Metastases in Pediatric Extracranial Solid Tumors: A 20-Year Experience in Challenging a Rare Diagnosis
Pages: 450-456
DOI: 10.5137/1019-5149.JTN.49617-25.5
AIM: To investigate the clinical features, treatments, and outcomes of pediatric patients with brain metastasis from extracranial solid tumors, which has been known as a rare condition. MATERIAL and METHODS: Over a 20-year period, 520 children treated for extracranial solid tumors in our radiotherap...
Neuroanatomy
Endoscopic Endonasal Approach to Identify the Medial Corridor of the Cavernous Sinus: A Cadaveric Study with Clinical Correlation
Pages: 457-466
DOI: 10.5137/1019-5149.JTN.49456-25.2
AIM: To define the existence and precise anatomical boundaries of the medial corridor (MC) within the cavernous sinus (CS), using an endoscopic endonasal transsphenoidal approach, and to correlate these anatomical findings with clinical patterns of CS invasion in patients with pituitary adenomas. MA...
Case Report
Pages: 467-470
DOI: 10.5137/1019-5149.JTN.48672-25.3
Takayasu arteritis (TA) is a chronic granulomatous large-vessel vasculitis that primarily affects the aorta and its major branches, such as the subclavian, carotid, and renal arteries. Pathologically, it is characterized by transmural infiltration of lymphocytes and macrophages with granulomatous in...
Pages: 471-475
DOI: 10.5137/1019-5149.JTN.47954-24.0
Loeys-Dietz Syndrome (LDS) is a rare, autosomal dominant connective tissue disorder with an estimated prevalence of less than 1 in 100,000. LDS results from one of several genetic mutations altering the transforming growth factor β (TGF-β) signaling pathway. LDS portends a higher risk of v...
Pages: 476-482
DOI: 10.5137/1019-5149.JTN.48836-25.2
Penetrating cerebrovascular injuries (PCVIs) are often life-threatening, with trauma to the carotid or vertebral arteries potentially causing severe neurological deficits. This study aimed to retrospectively examine two cases of severe penetrating cerebrovascular injury with unstable hemodynamics th...
Pages: 483-488
DOI: 10.5137/1019-5149.JTN.49346-25.2
Meningiomas, which are the most common primary intracranial tumors, frequently arise from the dura of the convexities, parasagittal regions, and skull base. The accessory nerve (cranial nerve XI) at the level of the foramen magnum is an exceptionally uncommon site of origin. To date, only a few case...
Obituary
Pages: 489
DOI: 10.5137/1019-5149.JTN.49720-25.2
Dr. Zeki Oral was born in Anamur in 1940. He completed his primary and secondary education in Anamur and his high school education in Bursa. In 1966, he graduated from Istanbul Faculty of Medicine and, in the same year, began his neurosurgery residency at Hacettepe Faculty of Medicine. Following his...